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Case Report

Epidermoid squamous cell carcinoma after pulmonary tuberculosis infection

Carcinoma espinocelular epidermóide após infecçao por tuberculose pulmonar

Marcus Henrique Bandeira Dourado; Murilo Lima Barbosa Diniz Romero; Marlon Ferreira Santos; Ronan Lacerda Barbosa; Adriano Rêgo Lima de Medeiros

DOI: 10.5935/1806-6054.20190017

ABSTRACT

A 64-year-old female patient with uncompensated fever and secretive cough, an active smoker with a history of tuberculosis treated irregularly, developed non-small cell lung cancer such as squamous cell carcinoma in the pulmonary cavernoma.

Keywords: Carcinoma; Tuberculosis; Cavitation.

RESUMO

Paciente do sexo feminino, 64 anos, com febre descompensada e tosse discreta, fumante ativo com histórico de tuberculose tratada de forma irregular, desenvolveu câncer de pulmao de células nao pequenas, bem como carcinoma de células escamosas em cavernoma pulmonar.

Palavras-chave: Carcinoma; Tuberculose; Cavitaçao.

INTRODUCTION

Tuberculosis (TB) and Lung Cancer (LC) are two important causes of incidence and morbidity and mortality in developing countries. Estimates in the year of 2017 point to about 10 million people affected by TB and about 1,3 million deaths worldwide.1,2 In Brazil, in 2018, there were 72.788 new cases of TB, which represents an incidence coefficient of 34,8 cases/100 thousand inhabitants. Despite a slight reduction in the incidence of the disease, by 1% from 2009 to 2018, are still significantly higher than the goals of Strategy for Ending Tuberculosis proposed by the World Health Organization.3

In relation to LC, the World Health Organization (WHO) pointed to the year of 2016 approximately 1,7 million cases diagnosed in the world and in Brazil, for the same period, the estimate was approximately 17,4 thousand new cases in males and 11 thousand in females.4

Both TB and LC have clinical presentations that course with consumptive symptoms and radiological findings of pulmonary nodules. Thus, these pathologies constitute important differential diagnoses.5

Although the joint occurrence of these two pathologies is rare, about 2%,6 it is known that patients with tuberculosis have a two-fold increased risk of developing lung cancer.7

Thus, this work describes the case of a patient with epidermoid squamous cell carcinoma developed in tuberculosis infection scar.

 

CASE REPORT

Female of 64-year-old, rural worker, with history of secretive cough for 3 years, associated with unverified fever, especially in the afternoon/night period, of sporadic character and significant weight loss (she could not tell how much). History of active smoking and high smoking burden, using hand-rolled tobacco (1 pack of straw cigarette every two days) for about 45 years. After 2 years with the symptomatology, sought medical attention at the Primary Health Unit, where laboratory tests were requested, which showed no significant changes, bacilloscopy, positive in 3rd sample and chest X-ray with image suggestive of pulmonary tuberculosis (Figure 1). Was prescribed TB treatment, but without therapeutic adherence by the patient.

 


Figure 1. PA and lateral chest X-ray - Heterogeneous opacity with cavitation in right upper middle lobe (arrow).

 

About 1 year later she sought hospital care complaining of chest pain, associated with coughing episodes with elimination of mucosanguinolent discharge and intense adynamia. After symptomatic control and realization of new control chest X-ray and Computed Tomography (CT) of the chest (Figures 2A and 2B), she was referred to the thoracic surgery service, in which performed bronchoscopy and biopsy of the lesion, whose result revealed lung fragments and bronchial mucosa suggestive of well-differentiated and invasive epidermoid squamous cell carcinoma, with foci of necrosis, associated with interstitial inflammatory infiltrate. After that, the patient was referred to the oncology service for clinical follow-up.

 


Figure 2A. Chest CT coronal view - Large cavity lesion approximately 12cm in diameter, thick and irregular walls, adherent to the right chest wall, with extensive pleural infiltration and liquid content inside, doing hydro level (arrow).

 

 


Figure 2B. Chest CT transverse - Large cavity lesion approximately 12cm in diameter, thick and irregular walls, adherent to the right chest wall, with extensive pleural infiltration and liquid content inside, doing hydro level (arrow).

 

DISCUSSION

Lung cancer is the leading cause of cancer death in Brazil and worldwide, with about 1,3 million deaths a year. Tuberculosis is also an important cause of morbidity and mortality, especially in developing countries.1,2,4

The explanation for the development of lung cancer in patients with TB is commented by several authors, which state that some reactive oxygen or nitrogen species when released by activated neutrophils, can bind to DNA, inducing genetic damage and, finally, neoplastic transformation.8 This was evidenced in the fragile histidine triad gene in patients with chronic TB.9

Silva et al, demonstrated in their study that the moment of diagnosis can be defined in three phases: simultaneous TB and LC, 41,7%; TB before LC, 58,3%; and LC before TB, none case.10 The simultaneous or not occurrence of TB and LC in the same patient has been described in other studies. This association may vary according to the region and ethnic groups.7

The clinical diagnosis of simultaneous occurrence can be difficult, considering that the symptoms and the lesions of TB may mask the diagnosis of lung cancer, thus delaying the diagnosis.11

Already radiological diagnosis has been a widely used method to evaluate both TB and LC patients. The chest X-ray is the initial method and CT is the follow-up method. A benign lesion may present with image of concentric or laminar calcification, diffuse or uniform, central and in "popcorn". Other types of calcification (eccentric and dotted), when identified, should be

considered potentially malignant. When assessing the morphology of nodular lesions, it is observed that most of those, larger than 2cm, constitute malignant nodules. In addition, malignant lesions are often illdefined, irregular and with spiky edges.12

Some authors suggest periodic follow-up with chest X-ray, bronchoscopy with biopsy and sputum cytology in patients recently diagnosed with tuberculosis to allow an early diagnosis of lung cancer.13 Others claim that the use of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUSTBNA) is a good option, considering that for TB it has a sensitivity of 85%14 and an accuracy of 93,9% for malignant diseases.15

In most of the studies observed, there was a greater association between TB and adenocarcinoma, something different from that reported above, which showed an association with squamous cell carcinoma. Another important factor to highlight is the history of smoking (active or in the past), whereas even after practice control there is still a 2,5-fold increased risk of cancer in TB patients.16

From this analysis, it highlights the importance of health actions regarding the orientation of patients diagnosed with tuberculosis regarding exposure to pulmonary carcinoid substances, such as smoking, as well as the adequate treatment of infection with the objective of increasing their overall survival and decrease the impact on public health.

 

REFERENCES

1. World Health Organization (WHO). Global Tuberculosis Control: Epidemiology, Strategy, Financing [Internet]. Geneva: WHO Report; 2009; [cited 2018 Dec DIA]. Available from: http://whqlibdoc.who.int/publications/2009/9789241563802_eng_doc.pdf

2. World Health Organization (WHO). Global Tuberculosis - Report 2018. Geneva: WHO; 2018; [cited ANO mês DIA]. Disponível em: http://www.who.int/iris/handle/10665/274453

3. Ministério da Saúde (BR). Secretaria de Vigilância em Saúde. Boletim Epidemiológico. Brasil Livre da Tuberculose: evoluçao dos cenários epidemiológicos e operacionais da doença. 2019 Mar;50(9).

4. Instituto Nacional de Câncer (INCA). Estimativas 2016: Incidência de Câncer no Brasil [Internet]. Rio de Janeiro: INCA; 2016; [cited 2018 Dec DIA]. Available from: www.inca.gov.br

5. Homrich GK. Prevalência de doenças que simulam câncer de pulmao: experiência de um Hospital Universitário da Regiao Sul do Brasil [dissertaçao]. Rio Grande do Sul (RS): Universidade Federal de Santa Maria, Centro de Ciências da Saúde, Programa de Pós-graduaçao e Ciências da Saúde; 2013.

6. Shiels MS, Albanes D, Virtamo J, Engels EA. Increased risk of lung cancer in men with tuberculosis in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):672-678. DOI: https://doi.org/10.1158/1055-9965.EPI-10-1166

7. Brenner AV, Wang Z, Kleinerman RA, Wang L, Zhang S, Metayer C, et al. Previous pulmonary diseases and risk of lung cancer in Gansu Province, China. Int J Epidemiol. 2001;30(1):118-24. DOI: https://doi.org/10.1093/ije/30.1.118

8. Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007 May;117(5):1175-83. DOI: https://doi.org/10.1172/JCI31537

9. Nalbandian A, Yan BS, Pichugin A, Bronson RT, Kramnik I. Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control. Oncogene. 2009 Apr;28(17):1928- 38. DOI: https://doi.org/10.1038/onc.2009.32

10. Silva DR, Valentini Júnior DF, Müller AM, Almeida CPB, Dalcin PTR. Tuberculose pulmonar e câncer de pulmao: ocorrência simultânea ou sequencial. J Bras Pneumol. 2013 Aug;39(4):484-489. DOI: https://doi.org/10.1590/S1806-37132013000400013

11. Rihawi A, Huang G, Al-Hajj A, Bootwala Z. A case of tuberculosis and adenocarcinoma coexisting in the same lung lobe. Int J Mycobacteriol. 2016;5(1):80-2. DOI: https://doi.org/10.1016/j.ijmyco.2015.07.001

12. Barcellos MG. Radiologia do câncer de pulmao. J Pneumologia. 2002 Apr;28(2):94-99. DOI: https://doi.org/10.1590/S0102-35862002000200006

13. Cicenas S, Vencevicius V. Lung cancer in patients with tuberculosis. World J Surg Oncol. 2007 Feb;5:22. DOI: https://doi.org/10.1186/1477-7819-5-22

14. Ortakoylu MG, Iliaz S, Bahadir A, Aslan A, Iliaz R, Ozgul MA, Urer HN. Valor diagnóstico da punçao aspirativa por agulha guiada por ultrassom endobrônquico em diferentes doenças pulmonares. J Bras Pneumol. 2015 Oct;41(5):410-414. DOI: https://doi.org/10.1590/S1806-37132015000004493

15. Choi YR, An JY, Kim MK, Han HS, Lee KH, Kim SW, et al. The diagnostic efficacy and safety of endobronchial ultrasound-guided transbronchial needle aspiration as an initial diagnostic tool. Korean J Intern Med. 2013 Nov;28(6):660-7. DOI: https://doi.org/10.3904/kjim.2013.28.6.660

16. Rybacka-Chabros B, Mandziuk S, Berger-Lukasiewicz A, Danko-Mrozinska M, Milanowski J. The coexistence of tuberculosis infection and lung cancer in patients treated in pulmonary department of Medical Academy in Lublin during last ten years (1990-2000). Folia Histochem Cytobiol. 2001;39(Suppl 2):73-4.

Received in December 12 2018.
Accepted em July 24 2019.

Financial support: none to declare

Conflicts of interest: The authors declare no conflict of interest relevant to this manuscript


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