Gynecologic cancers constitute an important burden of disease around the world. Estimates from GLOBOCAN 2018 reveals approximately 1,247,300 incident casesand 596,000 related deaths of cancers of the uterine cervix, corpus uteri, and ovarian, annually around the world. In 2018 lots of promising results to improve disease control have been presented at international gynecological cancer meetings. The current review highlights some of the top gynecologic cancer news of 2018, including the new standard of care for BRCAmutant ovarian cancer patients with maintenance olaparib in first line, benefit of bevacizumab rechallenge for relapsed ovarian cancer patients, and the unexpected results of worse overall survival with minimally invasive surgery in early cervical cancer, among others.
Keywords: Genital Neoplasms, Female. Review. Clinical Trial, Phase III.
Neuroendocrine tumors (NET) constitute a heterogeneous group of neoplasms with variable prognoses and clinical presentations. Therefore their therapeutic management is challenging, involving a real multidisciplinary approach composed of medical oncologists, surgeons, endocrinologists, nuclear medicine physicians and interventionist radiologists. Here in this article, we have summarized the studies that have changed (or are likely to influence) the clinical management of patients with NET in 2018: the new WHO pathology classification for pancreatic NET, the use of peptide receptor radionuclide therapy (PRRT) in G3 NET, re-treatment with PRRT, randomized data on the CapTem regimen and new data on carcinoid heart disease.
Keywords: Neuroendocrine Tumors. Malignant Carcinoid Syndrome. Antineoplastic Agents.
The Breast Cancer community witnessed the presentation of several important studies though 2018. From molecular evaluation of primary breast tissue to predict chemotherapy benefit, to major advances in systemic therapy in the metastatic setting, clinical trials highlighted in this BJO especial edition have truly major impact in current clinical practice for breast cancer patients.
Keywords: Breast Neoplasms. Review. Combined Modality Therapy.